Proteomics · Nature 2026

Microproteins and peptideins · 3D

3D 機制動畫：mRNA 非典型 ORF（ncORF）→ 核糖體轉譯微蛋白（peptidein）→ HLA-I 呈現到細胞表面 → T 細胞辨識 cryptic 抗原。3D mechanism animation: a non-canonical ORF (ncORF) on the mRNA → the ribosome translates a microprotein (peptidein) → loaded onto HLA-I at the cell surface → a T cell recognizes the cryptic antigen.
動畫導讀：這支動畫在演什麼What you're watching
  1. mRNA 絲帶上標示出一片短小的非編碼開放閱讀框區域。
  2. 核糖體正在翻譯該段 mRNA 並釋出一條微小蛋白質鏈。
  3. 微小蛋白質嵌入細胞表面的 HLA 第一型分子中向外展示。
  4. T 細胞受體與 HLA 上的微小肽段結合並發出辨識光芒。
  1. An mRNA transcript ribbon with a short non-canonical ORF region highlighted (a uORF / lncRNA stretch)
  2. A ribosome sitting on that mRNA region, translating it, with a tiny microprotein (peptidein) chain emerging from the ribosome
  3. The small microprotein loaded into an HLA class I molecule on the cell surface, displayed outward from the cell membrane
  4. A T cell with its receptor docking onto the HLA-presented small peptide, recognizing the cryptic antigen, a subtle recognition glow
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原始出處 · Source

Deutsch EW, Kok LW, Mudge JM, et al. Expanding the human proteome with microproteins and peptideins. Nature (2026).

DOI: 10.1038/s41586-026-10459-x · 閱讀全文 →Read full text →

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