粒線體斑塊如何形成？

綠色粒線體逐漸受損並轉為黃色；溶酶體延遲靠近，未能及時清除，最後形成以黃色受損粒線體為主的斑塊。旁邊的藍色結構代表保持分離的 Aβ 斑塊。Green mitochondria become damaged and turn yellow. Lysosomes arrive late and fail to clear them in time, producing a plaque dominated by yellow damaged mitochondria. The separate blue structure represents an Aβ plaque.

固定色彩圖例Fixed color key

綠色：中性、較早期粒線體Green: neutral, earlier-stage mitochondria

黃色：受損粒線體；最終斑塊的主要顏色Yellow: damaged mitochondria; the dominant final-plaque color

橙色：少量酸化、清除不完整的粒線體Orange: a smaller acidified, incompletely cleared subset

紫色：延遲抵達的溶酶體Purple: lysosomes recruited late

藍色：保持分離的 Aβ 類澱粉斑塊Blue: a separate Aβ plaque

顏色是教育性視覺編碼，不是疾病嚴重程度的量測值。Colors are educational visual encodings, not measurements of disease severity.

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原始出處Source

Dan X. et al. (2026). Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer’s disease. Nature Neuroscience.

DOI 10.1038/s41593-026-02390-1