動畫導讀：這支動畫在演什麼What you're watching
- 3D 突觸末端畫面中，粒線體 (紅色)內的 Complex I 蛋白結構變暗，呈現受損狀態。
- 粒線體周圍的 ROS (洋紅色)球體發光，從粒線體釋放並往神經與肌肉區域擴散。
- ROS (洋紅色)球體接觸突觸前膜，白色 Bruchpilot 蛋白群在膜上密集堆積成強化區。
- ROS (洋紅色)球體作用在突觸後肌肉膜，scaffold (紫色)網狀結構破碎，glutamate receptor (藍色)群脫離膜面。
- A detailed 3D view of a synaptic terminal where a red-colored mitochondria contains a darkened, failing protein structure representing Mitochondrial Complex I depletion
- The failing mitochondria begins to pulsate and release a cloud of glowing magenta spheres, representing Reactive Oxygen Species (ROS), which drift throughout the nerve and muscle compartments
- Inside the presynaptic nerve terminal, the magenta spheres trigger the accumulation of dense, white protein clusters known as Bruchpilot at the membrane, creating reinforced signaling zones
- On the postsynaptic muscle surface, the magenta spheres dissolve a purple mesh-like structural scaffold, causing blue glutamate receptor clusters to detach and disappear from the membrane
原始出處 · Source
Mallik B, Bhat SA, Wang X, Frank CA (2025) Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms. PLoS Biol 23(9): e3003388. https://doi.org/10.1371/journal.pbio.3003388
DOI: 10.1371/journal.pbio.3003388 · 閱讀全文 →Read full text →
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