動畫導讀：這支動畫在演什麼What you're watching
- 在神經細胞核內，活化的 Caspase-4 酵素靠近與 RNA 結合的完整 TDP-43 蛋白質。
- Caspase-4 酵素對接並切割 TDP-43 蛋白質，使其分解成碎片。
- 切斷後的 TDP-43 片段穿過核孔，由細胞核進入周圍的細胞質中。
- 細胞質中的 TDP-43 片段聚集成深色團塊，神經元結構開始退化。
- A detailed view of a neuron's nucleus where active human Caspase-4 enzymes hover near healthy, full-length TDP-43 proteins bound to RNA
- The Caspase-4 enzymes dock onto the TDP-43 proteins, causing them to be cleaved into smaller, truncated protein fragments
- The truncated TDP-43 fragments migrate through the nuclear pores and exit into the surrounding liquid cytoplasm
- In the cytoplasm, the TDP-43 fragments cluster together into dense, dark protein aggregates as the neuron's structure begins to degenerate
原始出處 · Source
Jia, Q., Zhu, L., Li, D. et al. Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology. Nature Communications (2026).
DOI: 10.1038/s41467-026-73724-7 · 閱讀全文 →Read full text →
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