Translational Psychiatry · Review · 2025

Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders · 3D

3D 機制動畫:依照論文分鏡呈現核心生物機制。3D mechanism animation: the paper's core biological mechanism shown from the storyboard.
  1. 顯微鏡下的腸道腔室中,多樣的桿狀細菌正在將膳食纖維轉化為發光的微小球體。
  2. 發光球體穿過半透明的腸道細胞壁,並進入搏動中的紅色血管。
  3. 在大腦微血管內,球體沿著血管壁移動並滲透進緻密的波浪狀血腦屏障。
  4. 發光球體出現在屏障的神經側,並與分支狀的微膠細胞及星狀細胞表面的受體結合。
  1. A microscopic view of the gut lumen where diverse rod-shaped bacteria are fermenting dietary fiber into small, glowing spheres representing short-chain fatty acid metabolites
  2. The glowing spheres migrate from the intestinal environment through a semi-permeable cellular wall and enter a pulsing red blood vessel
  3. Inside a brain capillary, the spheres travel along the vessel wall and begin to penetrate a dense, wavy protective structure representing the blood-brain barrier
  4. The spheres emerge on the neural side of the barrier and bind to specialized receptors on the surfaces of branching microglia and star-shaped astrocytes

Jabbari Shiadeh SM, Chan WK, Rasmusson S, et al. Translational Psychiatry 15, 278 (2025).

DOI: 10.1038/s41398-025-03504-2 · 查看 PubMed →View on PubMed →

本頁為教育性整理,非原文翻譯;原文版權屬原出版方。An educational summary, not a translation; copyright remains with the original publisher.

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