動畫導讀：這支動畫在演什麼What you're watching
- 特寫單個 α-突觸核蛋白鏈在神經環境中發生錯誤摺疊，並自組裝成緻密的螺旋狀類澱粉纖維。
- 在細胞質中漂浮且發光的 ATP 分子，被類澱粉纖維表面規律的化學溝槽與活性位點捕捉。
- 結合在纖維表面的 ATP 分子化學鍵斷裂，釋放出失去原有亮度且色澤黯淡的較小 ADP 與 AMP 分子。
- 隨著內部能量耗盡，背景的多巴胺神經元變得灰暗透明，僅留下深色且僵硬的類澱粉纖維結構。
- Close-up of individual alpha-synuclein protein chains misfolding and self-assembling into a dense, spiraling amyloid fibril within a neural environment
- Glow-emitting ATP molecules floating in the cytoplasm are captured by the ordered chemical grooves and active sites on the surface of the alpha-synuclein amyloid fibril
- Chemical bonds of the bound ATP molecules break apart at the fibril surface, releasing smaller ADP and AMP molecules that lose their bright luminescence and turn dull
- The background dopaminergic neuron turns grey and translucent as its internal energy stores vanish, leaving behind the dark, rigid structure of the growing amyloid fibrils
原始出處 · Source
Castillo-Cáceres, C. et al. Alpha-synuclein amyloids catalyze nucleotide degradation. Scientific Reports (2025).
DOI: 10.1038/s41598-025-32888-w · 閱讀全文 →Read full text →
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